Product ID:PHENYTOIN SODIUM INJECTION,U.S.P.
MSDS Date:06/03/1991
FSC:6505
NIIN:00-139-4348
MSDS Number: BWMNR

ABBOTT LABORATORIES, DIAGNOSTICS DIVISION

RT 43 AND 137
ABBOTT PARK, IL 60064-9078
US

Emergency Phone: 708-937-6100

Info Phone: 708-937-6100

Cage: 0ALT7

ABBOTT LABORATORIES DIAGNOSTICS DIV

NORTH CHICAGO, IL 60064-9078 US

Telephone: 800-323-9100

Cage: 0ALT7

PHENYTOIN SODIUM(50MG/ML)

CAS: 630-93-3

RTECS: MU1400000

ETHYL ALCOHOL (ETHANOL)

CAS: 64-17-5

RTECS: KQ6300000

OSHA PEL 1000 PPM

ACGIH TLV: 1000 PPM; 9394

PROPYLENE GLYCOL

CAS: 57-55-6

RTECS: TY2000000

LD50 LC50 Mixture:ORAL LD50 (RAT) IS 1635MG/KG
Routes of Entry: Inhalation:NO Skin:NO Ingestion:NO
Reports of Carcinogenicity:NTP:YES IARC:NO OSHA:NO
Health Hazards Acute and Chronic:EYES:MAY CAUSE IRRITATION.SKIN:MAY
CAUSE IRRITATION AND ALLERGIC SENSITIZATION.INGEST:MAY CAUSE GI
TRACT IRRITATION.INHAL:MAY CAUSE RESPIRATORY
IRRITATION.CHRONIC:PHENYTOIN HAS BEEN SHOWN TO CAUSE REP RODUCTIVE
DAMAGE.ALSO,IT MAY ELLICIT SEVERE HEART REACTION IN THE ELDERLY AND
GRAVELY ILL.ETHANOL MAY DAMAGE THE LIVER.
Explanation of Carcinogenicity:PHENYTOIN IS LISTED BY NTP BECAUSE IT
PRODUCES LYMPHOMAS AND LEUKEMIA IN MICE.
Effects of Overexposure:REPRODUCTIVE DAMAGE:OFFSPRING WITH CLEFT
PALLETTE,MALFORMED HEART AND FETAL HYDANTOIN
SYNDROME.OVERDOSE:TREMOR,LETHARGY,SLURRED
SPEECH,NAUSEA,VOMITING,COMA,HYPERTENSION,RASHES,GINGIVAL
HYPERPLASIA.
Medical Cond Aggravated by Exposure:PERSONS WITH PRE-EXISTING
HYPERSENSITIVITY TO HYDANTOINS OR HEART DISEASE OR ALCOHOLISM MAY
BE AT INCREASED RISK FROM EXPOSURE.

First Aid:SKIN:REMOVE CONTAMINATED CLOTHING;WASH WITH WATER.EYES:FLUSH
WITH WATER FOR 15 MINUTES.INHAL:REMOVE TO FRESH AIR.GIVE OXYGEN OR
ARTIFICIAL RESPIRATION IF NEEDED.INGEST:DO NOT INDUCE VOMITING.GET
PROMP T QUALIFIED MEDICAL ATTENTION.PROVIDE SUPPORTIVE CARE;MONITOR
HEART AND LUNG FUNCTIONS.

Flash Point Method:COC
Flash Point:=12.7C, 54.9F
Extinguishing Media:WATER,CARBON DIOXIDE,FOAM.
Fire Fighting Procedures:USE A SELF-CONTAINED BREATHING APPARATUS AND
FULL PROTECTIVE EQUIPMENT.
Unusual Fire/Explosion Hazard:FIRE CONDITIONS MAY EVOLVE TOXIC FUMES.

Spill Release Procedures:ELIMINATE SOURCES OF IGNITION.SOAK UP WITH
NON-COMBUSTIBLE INERT ADSORBANT(EG.CLAY);PLACE COLLECTED MATERIAL
IN AN APPROPRIATE CONTAINER FOR DISPOSAL;CLEAN SPILL AREA TO REMOVE
SLIPPERINESS.
Neutralizing Agent:NOT APPLICABLE.

Handling and Storage Precautions:STORE IN A COOL,DRY,WELL-VENTILATED
PLACE.KEEP CONTAINER CLOSED WHEN NOT IN USE.KEEP AWAY FROM
HEAT,SPARKS,FLAMES AND INCOMPATIBLE MATERIALS.
Other Precautions:FOLLOW LABEL DIRECTIONS.

Respiratory Protection:NOT NEEDED IN NORMAL SERVICE.
Ventilation:NO SPECIAL REQUIREMENTS
Protective Gloves:RUBBER
Eye Protection:SAFETY GLASSES
Other Protective Equipment:PROVIDE A LOCAL EYE WASH STATION.
Work Hygienic Practices:USE REASONABLE CARE IN HANDLING THIS
PRODUCT.WASH HANDS AFTER USE AND BEFORE EATING.
Supplemental Safety and Health
NONE

HCC:F2
Boiling Pt:=77.8C, 172.F
Vapor Pres:43
Spec Gravity:1.0306
pH:10-12
Viscosity:5.3 CPS
Solubility in Water:NEGLIGIBLE
Appearance and Odor:LIQUID;CLEAR.ODOR NOT REPORTED.
Percent Volatiles by Volume:10

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZING AGENTS.
Stability Condition to Avoid:HIGH HEAT,SOURCES OF IGNITION.
Hazardous Decomposition Products:OXIDES OF NITROGEN.

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE WITH FEDERAL,STATE AND
LOCAL REGULATIONS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.